Lung disease is any problem in the lungs or that prevents the lungs from working properly.
What is Lung?
The Lungs are the essential respiratory organ in air breathing living beings and lungs are a pair of spongy, air-filled organs, located near the backbone on either side of the heart. Trachea (windpipe) conducts inhaled air into the lungs through its tubular branches called bronchi. The bronchi then divide into smaller and smaller (bronchioles), finally becoming microscope. The principal function is to transport oxygen from the atmosphere into the bloodstream , and to release CO2 from the bloodstream into the atmosphere.
There is one another type of cells alveoli in lungs where all bronchioles end in cluster. In alveoli, oxygen from air is absorbed into the blood and CO2 which is waste product of metabolism, travels from the blood to the alveoli, where it can be exhaled. Between the alveoli is a thin layer of cells called interstitium, which contains blood vessels and cells that help support the alveoli.
The lungs are covered by a thin tissue layer called pleura, a thin layer of fluid acts as a lubricant allowing the lungs to slip smoothly as they expand and contract with each breath.
LUNG OR Pulmonary Disease and stem cells : –
Lung disease is leading causes of morbidity and mortality worldwide. Pulmonary diseases characterized by loss of lung elasticity, small airway tethers, and luminal obstruction with inflammatory mucoid secretions and excessive matrix deposition and destruction of the normal lung architecture.
Regeneration of pulmonary tissue by stem cells transplantation from endogenous, exogenous, is a promising novel therapy. The use of adult stem cells to help with lung regeneration and repair could be a newer technology in clinical and regenerative medicine. In fact, different studies have shown that stem cells contribute to repair and remodeling of lung in animal and human models of progressive pulmonary diseases.
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